• Users Online: 20
  • Print this page
  • Email this page
REVIEW ARTICLE
Year : 2021  |  Volume : 8  |  Issue : 1  |  Page : 5

New insights into the immunity and podocyte in glomerular health and disease: From pathogenesis to therapy in proteinuric kidney disease


Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

Correspondence Address:
Dr. Xuefei Tian
300 Cedar St., TAC S370, New Haven, Connecticut 06519
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/imna.imna_26_21

Rights and Permissions

Evidence has been furnished that immune cells, and immune-podocytes interactions have increasingly become the focus of proteinuric kidney diseases, which affect millions of patients worldwide. Podocytes are highly specialized, terminally differentiated epithelial cells that wrap around the glomerulus to maintain the integrity of the glomerular filtration barrier. More recent studies demonstrate that podocytes express many elements of the innate and adaptive immune system including the complement components and receptors, through which podocytes can be involved in immune-mediated glomerular injuries and as a therapeutic target to alleviate the podocyte injury and progression to chronic kidney disease. The present review will shed light on recent findings, which have furthered our understanding of the immune mechanisms involved in podocyte injury, as well as the therapeutic implications in the treatment of immune-mediated glomerular injury.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed517    
    Printed0    
    Emailed0    
    PDF Downloaded55    
    Comments [Add]    

Recommend this journal